6 Plug in the Numbers: Required Clinical Inputs for the PREVENT Equations For accurate use of the PREVENT online calculator, the following clinical data is required: Sex: Male or female (based on sex assigned at birth) Age: 30 to 79 years Total cholesterol: 130-320 mg/dL HDL cholesterol: 20-100 mg/dL Systolic blood pressure: 90-200 mm Hg Diabetes status (any history of diabetes): Yes or no Smoking status (any cigarette use within the last 30 days): Yes or no Body mass index (BMI): 18.5-39.9 kg/m2 Estimated glomerular filtration rate (eGFR): 15-140 mL/min/1.73m2 Lipid-lowering medication (current use of statin medications to lower cholesterol): Yes or no Antihypertensive medication use (current use of any medication for hypertension): Yes or no Situation-Dependent PREVENT Clinical Data To further personalize risk assessment, clinicians can input the following optional data when clinically indicated and available by selecting “yes” and entering the value: Urine albumin-creatinine ratio (UACR): 0-25000 mg/g UACR is clinically indicated for people with chronic kidney disease, diabetes or hypertension. If UACR is unavailable for eligible patients, consider this a gap-closure opportunity and obtain testing before or alongside PREVENT equation use to support a more complete risk assessment. Hemoglobin A1c (HbA1c): 3-15% HbA1c is clinically indicated for people with diabetes, prediabetes, overweight or obesity, or a history of gestational diabetes. ZIP code (valid five-digit U.S. ZIP code) ZIP code is used to estimate Social Deprivation Index (SDI), a composite measure to quantify neighborhood-level socioeconomic disadvantage. Who Is Eligible for Risk Estimation Using the PREVENT Equations? Because the PREVENT equations are validated for adults aged 30 to 79 years without known CVD, do not use the PREVENT equations for adults with known or severe subclinical CVD, such as left ventricular ejection fraction <40%, coronary artery calcium ≥300, end-stage kidney disease or limited life expectancy (<1 year). Also, do not use the equations for individuals aged <30 years or >79 years, for individuals with missing required variables or out-of-range values, for those with positive genetic testing for a variant known to be pathogenic or for an inherited cardiovascular condition. *Out-of-range values should be managed as clinically indicated. Risk can still be estimated with the closest in-range value but may represent an over- or under-estimate.
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