Clinical research faces stiff headwinds. Trials are growing costlier. The questions they address are trickier. Recruitment can be slow. And greater inclusivity is essential. But adaptation and innovation will help stroke scientists meet the moment, speakers at ISC25 say. Although traditional methodologies in randomized clinical trials (RCTs) increasingly face hurdles, innovative solutions to enhance the design and execution of stroke trials exist, according to Nishita Singh, MD, an assistant professor of neurology at the University of Manitoba in Winnipeg. “RCTs are struggling to keep pace with evolving needs. The clinical questions we face today are far more complex than before,” Singh said. “For example, we need to address tailored interventions for patients with unique characteristics, such as those with minor strokes, unusual clot locations or co-existing conditions like pre-morbid disability or cognitive impairment. These situations often require trial designs that traditional RCTs are not equipped to handle efficiently.” Singh is among the speakers Wednesday at the session “Modernizing Stroke Trials for the 21st Century: Scale, Strategy and Technology.” Her presentation, “Innovative Consent see MODERNIZING, page 14 Nursing, rehabilitation and health care professionals met in Los Angeles Tuesday to explore nursing issues along the continuum of stroke care, the impact of stroke nurses across the globe, post-acute stroke recovery, primary and secondary prevention, ischemic and hemorrhagic stroke management, rehabilitation and program development. INSIDE News ISC25 awardees honored Overcoming post-stroke cognitive impairment 12 6 Stroke advancements in children remain a challenge 3 Poster tours, sessions kick off today 10 Science & Technology Hall map and exhibitor list Pages 8-9 Wednesday, Feb. 5 DAY 1 The Paola De Rango Session | Improving stroke care for women 5 See photos of your colleagues and friends at ISC 2025 in Los Angeles. VIEW PHOTOS FROM #ISC25 Nursing Symposium opens #ISC25 Conference International Stroke Overhauling traditional random clinical trials Pursuing innovative solutions could improve efficiency, inclusivity and patient care. Modernizing Stroke Trials for the 21st Century: Scale, Strategy and Technology 2-3 p.m. Wednesday, Feb. 5 Main Event Hall UPCOMING SESSION Singh
2 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 Three pre-cons covered the stroke bases: Fast and Furious Stroke in the Real World, Ready, Set, Translate Stroke in the Lab World and HEADS-UP: Health Equity and Actionable Disparities in Stroke. Virginia J. Howard, PhD, FAHA, (center) is recognized during the HEADS-UP pre-con by Amytis Towfighi, MD, FAHA, (left) and Janet A. Prvu Bettger, ScD, FAHA. LB1 | Procedural, Safety and Functional Outcomes Following Minimally Invasive Surgery for Deep and Lobar Intracranial Hemorrhages: MIND Study Results Adam S. Arthur, Semmes-Murphey Clinic, Memphis, Tennessee LB2 | Transradial Versus Transfemoral Arterial Access for Cerebral Angiography Wei Ni, Huashan Hospital, Fudan University, Shanghai, China LB3 | Endovascular Therapy Plus Best Medical Treatment Versus Best Medical Treatment Alone for Medium Distal Vessel Occlusion Stroke Marios Psychogios, University Hospital Basel, Basel, Switzerland LB4 | Endovascular Treatment to Improve Outcomes for Medium Vessel Occlusions: The ESCAPEMeVO Trial Mayank Goyal, University of Calgary, Calgary, AB, Canada LB47 | Mechanical Thrombectomy in Acute Ischemic Stroke Related to a Distal Occlusion: Interim Analysis of the DISCOUNT Randomized Controlled Trial Frédéric Clarençon, Pitié-Salpêtrière Hospital, Paris, France Learning Studios and industry symposia 9:30-10:30 a.m. Left Atrial Appendage Closure and the Heart-Brain Connection Supporter: Boston Scientific Corporation Learning Studio I 9:30-10:30 a.m. Health Wanted: AHA Resources to Spark Community Dialogue About Rural Health Inequities Supporter: AHA Health Equity Learning Studio II in Room 306AB 12:45-1:15 p.m. From Concept to Care: Implementing Effective Cardiac Monitoring Pathways Supporter: Medtronic Learning Studio I 12:45-1:15 p.m. Using Predictive Analytics to Improve Clinical Outcomes Supporter: Encompass Health Corporation Learning Studio II in Meeting Room 306AB 1:30-2 p.m. Can We Bridge the Gap? Implementing New Approaches to Address Women’s Needs in Stroke Trials Supporter: BMS/Janssen Alliance Learning Studio I 1:30-2 p.m. Enhanced Perspectives: Advanced Visualization Through Deep Clinical AI Supporter: Rapid AI Learning Studio II in Meeting Room 306AB 2:15-2:45 p.m. Pioneering Stroke Care: Insights From the Creators and Implementers of Mobile Stroke Ambulances Supporter: NeuroLogica Learning Studio I 3:30-4 p.m. Insights From the Field: The Life of a Teleneurologist Supporter: TeleSpecialists Learning Studio I 6-7:30 p.m. Best Practices for Managing Intracerebral Hemorrhage Sponsor: Voxmedia AC Hotel Downtown Los Angeles, Meeting Event Space, Seventh Floor Learning Studios WEDNESDAY, FEB. 5 WEDNESDAY, FEB. 5 11 a.m.-12:35 p.m. | Main Event Hall Late-Breaking Science Visit the Simulation Zone Realistic hands-on learning guided by expert faculty. Practice vascular access and navigation or procedural skills, including deployment of stents and coils, clot aspiration and so much more! Participating companies include Balt, Johnson & Johnson MedTech, Mentice, SurgeonsLab, Terumo Neuro and United Biologics. Attendees engage in Tuesday’s pre-con selections Wednesday, Feb. 5 9:15-10:45 a.m. 2-3:30 p.m. Thursday, Feb. 6 11 a.m.-12:30 p.m. 1:30-3 p.m. Booth 1047
3 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 Advances in managing adult ischemic stroke have been countless. But it’s a different story in pediatric stroke, where numerous uncertainties remain. Although youth is perceived as an advantage in stroke recovery, young patients have high rates of mortality and disability, said Rachel Pearson, MD, assistant clinical professor of pediatrics at the University of California, Irvine, and pediatric neurologist at Children’s Hospital of Orange County. Pearson is among the presenters at a session Wednesday on pediatric ischemic stroke. In her presentation “Challenges and Advances in Prehospital Care for Pediatric Stroke,” she will break down uncertainties and strategies to move forward. “There is a misconception that children with stroke ‘do better’ than adults in terms of recovery,” she said. “Although this can be true in some cases, many children have persistent neurological and/or neurodevelopmental impairments that they will carry with them for a lifetime. Such stroke-related disability not only affects these children and their families but also comes with significant long-term health care costs and resource utilization.” Pearson said pediatric stroke diagnosis is often delayed because of factors including lack of awareness, frequency of stroke mimics in children, variability in clinical presentation and the need for MRI as the preferred diagnostic modality for pediatric ischemic stroke. Timely and accurate diagnosis is essential for modern stroke interventions such as thrombolysis and endovascular thrombectomy to succeed. Achieving rapid diagnosis of stroke in children starts at the first point of contact, which is often in the emergency department or a prehospital setting, Pearson said. “We first must increase awareness and knowledge of those in the community, first responders and emergency department providers,” she said. “To do this, it is critical to collaborate with local and regional partners like public health care agencies, emergency medical services and community emergency departments. In creating such partnerships, we can spread education and develop processes of care to improve pediatric stroke recognition, diagnosis and treatment.” Pearson notes a few milestones in advancing pediatric ischemic stroke knowledge and care. For example, the International Pediatric Stroke Study — a multicenter, international, longitudinal, observational study and registry of pediatric stroke patients launched in 2003 — has broadened understanding of pediatric stroke epidemiology, risk factors and outcomes. And in 2019, the American Heart Association published its scientific statement on the Navigating the Pediatric Ischemic Stroke Landscape: Innovations in Prehospital and Intrahospital Management 2-3 p.m. Wednesday, Feb. 5 Room 502B UPCOMING SESSION Pearson Sporns see PEDIATRIC, page 14 Stroke advancements in children remain a challenge Focusing on pediatric differences versus adults is critical.
Total CME Full Page Page 4 Wed. Daily only REGISTER TODAY AT Reachmd.com/ISC2025 or scan the code above This event is not part of the official International Stroke Conference 2025 as planned by the International Stroke Conference Program Committee. Commercial Support: This activity is supported by independent educational grants from Bristol Myers Squibb and Johnson & Johnson Innovative Medicine Alliance. Shadi Yaghi, MD Co-Director, Comprehensive Stroke Center Director, Research at the Neurovascular Center Rhode Island Hospital Providence, RI Robin Novakovic, MD Professor of Radiology and Neurology UT Southwestern Medical Center Peter O’Donnell Jr. Brain Institute Dallas, TX M. Edip Gurol, MD, MSc Vascular Neurologist, Associate Professor of Neurology Director, High Hemorrhage Risk Stroke Prevention Clinic Director, Neuro-AFib Program Massachusetts General Hospital Harvard Medical School Boston, MA Jeffrey Weitz, MD Professor of Medicine & Biochemistry McMaster University Hamilton, ON, Canada FREE CME DINNER SYMPOSIUM Factoring Solutions to the Management of Stroke Care in the Settings of Secondary Prevention and AF Thursday, February 6, 2025 | 5:30-6:00 PM Dinner | 6:00-7:30 PM Symposium Paid Advertisement JW Marriott Los Angeles L.A. LIVE 900 W Olympic Blvd, Los Angeles, CA 90015 | Room: Gold 3-4 (Ground Level) Panelists Chair Provided By:
5 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 Peering into the health gap between the sexes, physicians and researchers see numerous questions that, when answered, could provide vital insights into stroke risk, prevention and outcomes in women. Exploring such questions, across women’s lives and through the course of their care, is the focus of the ISC’s annual Paola De Rango Session, which takes place on Wednesday. The goal is to increase awareness of sex and gender differences in stroke and to improve prevention and treatment in women. “One area of need to address (in women’s) health equity includes an improved understanding of how risk, resilience and recovery are modified by changes in women’s physiology throughout the lifespan,” said Thalia Field, MD, FRCPC, MHSc, an associate professor of neurology at the University of British Columbia in Vancouver. “This includes puberty and menstruation, pregnancy, menopause and its late effects on frailty.” “We also need to take a genderfocused lens to understand how sociocultural and other intersectional identity considerations interface with biological factors to impact wellness, illness and recovery,” said Field, who will discuss women’s health and cerebral venous thrombosis (CVT) on Wednesday. During the first half of the session, speakers will present data on four areas of study pertinent to stroke risk in women: management of carotid stenosis, sleep disorders and disruptions, gender-affirming hormone therapies and CVT. Critical sex differences exist in these areas but largely have been understudied, Field said. For example, both stroke risk associated with carotid disease and the efficacy of surgery for carotid stenosis differ by sex, yet women continue to be underenrolled in relevant clinical trials. Similarly, sleep disturbances are a stroke risk factor that disproportionately affects women during peri- and postmenopause, but more research is needed to design effective interventions. It’s also critical to understand more about treatment using hormone therapies. Evolving data indicate elevated risk of stroke and cardiovascular disease associated with gender-affirming hormone therapies. For CVT, a condition more prevalent in women, specific risk factors include iron deficiency anemia from menorrhagia, exogenous hormones, pregnancy and autoimmune disease. From 66% to 75% of people with CVT are women, usually younger, Field said, but this is because CVT is commonly seen in association with oral contraceptives, pregnancy and the postpartum period. Also, as with other types of stroke, women are more likely to have delays in correct diagnosis, she said. Register today for the Removing Barriers to Equitable Health eModules learn.heart.org Access for Free These free accredited activities will allow healthcare professionals to explore the disparities in health outcomes for various populations, examine how environmental factors and structural racism can create barriers to health, and discover best practices and solutions to help overcome those barriers. CE and MOC credits available This activity is supported by an educational grant from Bristol Myers Squibb. Module 2: Health Care Systems Module 1: Public Health PAID ADVERTISEMENT Improving stroke care for women Paola De Rango session delves into expanded areas of study. see PAOLA DE RANGO, page 15 The Paola De Rango Session: Understudied Factors Contributing to Disparities in Stroke Risk and Outcomes in Women Across the Continuum of Disease and Care 9:15-10:45 a.m. Wednesday, Feb. 5 Room 151 UPCOMING SESSION Field
6 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 Post-stroke cognitive impairment (PSCI) is common and disabling. Research suggests stroke might increase a person’s risk of dementia up to 50-fold. In fact, risk of dementia is higher than the risk of recurrent stroke. But in the absence of specific treatments for PSCI, aggressively preventing recurrent stroke by controlling vascular risk factors is a critical strategy to preserve mental acuity after stroke, according to Deborah A. Levine, MD, MPH, FACP, professor of medicine and neurology at the University of Michigan Medical School in Ann Arbor. On Wednesday, Levine will present “Epidemiology of Post-Stroke Cognitive Impairment: Prevalence, Trajectories and Outcomes” as part of the session “Post-Stroke Cognitive Impairment and Dementia: New Insights, Challenges and Opportunities.” Stroke can cause acute declines in executive function, memory, language, visuospatial function and processing speed, Levine said. About half the people who survive the acute phase of a stroke are left with significant cognitive dysfunction, including more than one-third of patients with moderate to severe stroke who have dementia at one year out. Even years after a stroke, more than 50% of patients report cognitive impairment. Estimates indicate stroke may lead to dementia diagnoses an average of 10 years earlier, compared with people who have not had strokes, and up to 25 years earlier in those who have had severe strokes. But even in the absence of dementia, PSCI is associated with increased mortality, disability and dependence, and worse quality of life. “We need more research to identify effective treatments to prevent and slow PSCI,” Levine said. Until such treatments are identified, Levine said, physicians should focus on preventing recurrent stroke by controlling patients’ vascular risk factors including high blood pressure, high cholesterol, diabetes and atrial fibrillation. “Recurrent strokes substantially increase post-stroke cognitive impairment and dementia risks. There is some evidence that cognitive rehabilitation can help improve language and comprehension deficits acutely after stroke,” she said. “We need more high-quality studies of cognitive rehabilitation to know what specific treatments, doses and durations are most effective, in which patients and during what time windows after stroke.” Levine’s research has found that higher post-stroke blood glucose levels were associated with faster post-stroke cognitive decline, independent of pre-stroke glucose and cognition levels. This suggests that improving glycemic control in stroke survivors is a potential strategy to reduce PSCI, though more research is needed, she said. Meanwhile, a randomized clinical trial has shown that isosorbide mononitrate and cilostazol reduced cognitive impairment after lacunar ischemic stroke, Levine said, suggesting that targeting cerebrovascular endothelial function might stem cognitive impairment in patients with symptomatic cerebral small vessel disease. Yet it’s clear that hyperacute stroke treatments won’t eradicate the cognitive consequences of stroke — there is significant residual disability even in patients who receive them, said Eric Smith, MD, FAHA, professor of neurology, radiology and community health sciences at the University of Calgary department of clinical neurosciences. That indicates a multimodal approach is needed to improve PSCI outcomes, said Smith, who will discuss “Cerebral Small Vessel Disease and Relationship to Post-Stroke Cognitive Outcomes — Epidemiology, Imaging, Biomarkers and Potential Therapeutic Targets” at the session Wednesday. “Pre-existing conditions, some of which may not even be recognized by the patient, can have a significant impact on the risk for post-stroke cognitive impairment,” Smith said. “Studies show that more than half of patients with their first symptomatic stroke have evidence on brain imaging of prior, silent strokes. For many patients, what they think is their first stroke is actually their second or third. We often refer to these imagingdefined strokes as ‘covert’ because they weren’t recognized by the patient but can have important, but insidious, effects on cognition.” In patients with new-onset dementia after stroke, signs of cerebral small vessel disease are more common than Alzheimer’s disease, Smith said. Post-Stroke Cognitive Impairment and Dementia: New Insights, Challenges and Opportunities 7:30-9 a.m. Wednesday, Feb. 5 Room 502A UPCOMING SESSION Levine Smith Become an AHA Certified Professional PAID ADVERTISEMENT Visit us at ISC in HeadQuarters and the VIP Lounge @Booth #1049 to learn more! Offer gold standard telehealth stroke care. Improve quality and consistency of care in telehealth stroke. Sign up to be a beta tester or volunteer in the development of the Stroke Coordinator Certification for a free hat. In Development: Stroke Coordinator Certification Overcoming post-stroke cognitive impairment Promise lies in the prevention of recurrent strokes. ISC News is produced for the American Heart Association/American Stroke Association’s International Stroke Conference by Ascend Media, LLC (ascendmedia.com). After you have read this issue of ISC News, please share with colleagues or deposit it in an approved paper recycling bin. ©2025 by the American Heart Association/American Stroke Association 7272 Greenville Ave. Dallas, TX 75231 1-888-4-STROKE stroke.org Paid advertisements are not reviewed by the AHA/ASA for scientific accuracy.
7 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 ISC 2025 is proud to extend the conversation across numerous topics with a growing number of international stroke societies. The expanded collaboration supports ISC’s mission to emphasize basic, clinical and translational science and taps an impressive network of professionals in understanding stroke pathophysiology, developing effective therapies and exploring brain health and stroke recovery. “We believe the insights and expertise of international organizations will significantly enrich the conversation,” said ISC Program Chair Lauren Hachmann Sansing, MD, MS, FAHA, FANA, professor of neurology and immunobiology at Yale University School of Medicine in New Haven, Connecticut. “Joint sessions with international organizations offer a unique platform for cross-pollination of ideas and foster collaborations that can accelerate advancements in the stroke community.” International sessions. Stroke Prevention in the United States and Europe (a European Stroke Organization/ASA Joint Symposium) 7:30 a.m. | Wednesday | Room 152 Stroke, Brain Health and the Brain Economy (an American Academy of Neurology/ASA Joint Symposium) 9:15 a.m. | Wednesday | Room 152 Advancements in Stroke Services — India: Quality Care, Best Practices and New Approaches (an Indian Stroke Association/ASA Joint Symposium) 4:45 p.m. | Wednesday | Room 152 East Asia Specific Forms of Stroke: RNF213-Related Vasculopathy (a Japan Stroke Society / ASA Joint Symposium) 7:30 a.m. | Thursday | Room 502B Professional Membership Learn how AHA/ASA Professional Membership can advance and enhance your career. Benefit from networking with experts, journal resources, online courses, research funding, advocacy, discounts to scientific meetings and more. Membership is valuable at every stage of your career. Join or renew at the Membership Booth in HeadQuarters and receive a thank-you gift (while supplies last). Scientific Journals Immediate impact. Global influence. When you visit AHAjournals.org, engage in the latest from the AHA/ASA Scientific Journals, learn about AHA’s scientific statements and clinical practice guidelines, and find everything you need to submit and publish in a journal! Scan the QR code for the Author Hub. For statements and guidelines, visit professional.heart.org/statements. Giveaways while supplies last. AHA International The association’s international team collaborates with 200 organizations, in over 100 countries, to improve the quality of stoke care. We educate health care professionals, influence policy changes and implement mission-driven programs to advance science and build stronger health care systems. Discover more about our international work in stroke center certification and health care quality improvement. heart.org/internationalQI Get With The Guidelines®-Stroke Get With The Guidelines-Stroke is the American Heart Association’s in-hospital quality improvement program focused on improving stroke care by providing medical teams with resources to increase adherence to the latest scientific treatment guidelines. Learn how hospitals can focus on targeting intracerebral hemorrhage with the ICH layer of Get With The Guidelines-Stroke! heart.org/gwtgstroke. Quality Improvement Research The American Heart Association’s suite of Quality Improvement Programs promote excellence in prospective and retrospective research. Participating hospitals can enter data for their quality improvement efforts. Additionally, there is the opportunity for scientific research from our National Level Database. The Precision Medicine Platform, the association’s cloud-based data analysis platform, offers secure, private workspaces equipped with tools for data analysis, machine learning and artificial intelligence. heart.org/qualityresearch. Visit HeadQuarters in Booth 528 AHA Center for Telehealth™ Evidence suggests that telehealth can make health care more effective, accessible and efficient, particularly for those who otherwise lack access to quality health care. Our premium eLearning courses and certification programs, including Telestroke, offer health care professionals standardized telehealth training and prepare them to deliver optimal virtual care. The AHA Center for Telehealth leads connected care, keeping people at the center. Heart.org/telehealth. AHA Research Grants The AHA currently funds more than 1,800 projects across the U.S. In FY 2023-24,the AHA invested $219 million to fund 1,100 new proposals. Our centennial anniversary allowed us to reach an all-time high in annual research funding. The AHA has invested over $5.9 billion in research since 1949. Discover funding opportunities and more at professional.heart.org/research. American Stroke Association Stroke is the No. 2 cause of death worldwide and a leading cause of disability. The ASA is a relentless force for a healthier world with fewer strokes. We team with millions of volunteers to prevent, treat and beat stroke by funding research, fighting for stronger public health policies, and providing lifesaving tools and information. Advanced Stroke Life Support (ASLS)® Stop by to learn about our newest stroke courses: ASLS Blended Learning Course, created to educate advanced health care professionals to identify, evaluate and manage patients with stroke, and Essential Stroke Life Support (ESLS)®, our newest eLearning course designed to teach basic health care providers knowledge for faster stroke recognition and triage for patients with stroke. Lifelong Learning Find on-demand educational activities, professional resources and more at learn.heart.org. Discover the types of continuing education available and why we are the premier provider of education for health care professionals. learn.heart.org. Patient Solutions Preview the latest educational resources for professionals and your patients in the areas of emotional support, atrial fibrillation, hypertension and more. Encourage your patients and their family members to join the Support Network at stroke.org/supportnetwork to connect with other patients, share experiences and help others on their health journeys. Professional Certification Your patients rely on your expertise for their well-being, and you are viewed by your peers and colleagues through the lens of your credentials and accomplishments. That’s why the American Heart Association launched its groundbreaking Certified Professional program. Designed as a vital supplement to your continuing education, Professional Certification from the AHA serves to further expand your expertise as a trusted care provider. heart.org/cpaha Forgot your Red? ShopHeart has you covered! Location: Science & Technology Hall, in HeadQuarters, for gifts and Heart items. Take center stage at #ISC25 with our 360-degree photo booth! Stop by the Charging Station to relax and recharge. NEW: ISC’s Neuro Talk Theater Sansing International reach Growing number of international stroke societies join #ISC25. Stroke in Indigenous and First Nations Populations (an Australian and New Zealand Stroke Organization/ ASA Joint Symposium) 2 p.m. | Thursday | Room 515A Stroke Care in the MENA Region: Challenges and Opportunities (a Middle East North Africa Stroke Organization/ASA Joint Symposium) 3:30 p.m. | Thursday | Room 502B 75 Years of NINDS-Supported Research to Advance Stroke Prevention, Treatment and Recovery: From Bench to Bedside and Beyond 3:30 p.m. | Thursday | Room 151 Establishing Stroke Centers of Excellence — Beyond Stroke Services and Quality (a World Stroke Organization/ASA Joint Symposium) 9:15 a.m. | Friday | Room 152
8 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 Access TeleCare . . . . . . . ....1122 Accreditation Commission for Health Care . . . . . . . .... 906 Adjacent Health . . . . . . ..... 807 Aidoc Medical Ltd. . . . . . . ... 923 American Association of Neuroscience Nurses (AANN) . . . . . . . 1002, 1004 American Board of Neuroscience Nursing (ABNN) . . . . . . ..... 1004 AmplifyMD..............817 Apex Innovations . . . . . . .... 600 Asahi Intecc USA . . . . . . ..... 801 Balt . . . . . . . . . . . .......1017 Bayer . . . . . . . . . . .....515, B11 Baylor Scott and White . . . . ... 316 Blue Sky Neurology . . . . . .... 300 BMS/J&J alliance . . . . .. 331, B1, B2 Boston Scientific . . . . . . . . . . . 318 Brain Aneurysm Foundation . . 1003 Brainomix...............811 Brainventions, Inc. . . . . . . . . 1006 Business Audio Theatre . . . . .. 423 CERENOVUS . . . . . . . . ..... 939 Ceribell . . . . . . . . . . ...... 802 Chiesi. . . . . . . . . . . ....... 311 Chiesi USA, Inc. Medical Affairs . . 310 DiaMedica Therapeutics, Inc. . . . 505 DNV.. .. .. .. .. ......... 501 DWLUSAInc. . . . . . . . ..... 800 Encompass Health Corporation . 901 Genentech . . . . . . . . . ...... 931 GENOBIOTX . . . . . . . . . . . . . 422 Genomadix Inc . . . . . . . ..... 513 Getting to the Heart of Stroke . . 400 Grace Therapeutics . . . . . . ...315 Harmony Healthcare IT . . . .. 1023 Health Scholars . . . . . . ..... 504 Hyperfine . . . . . . . . . . . . . . . 615 IDMED................1025 Image Monitoring USA . . . . . . . 500 Imperative Care . . . . . . . . . 917, B4 JAMA Network . . . . . . . . .... 606 JLKInc. . . . . . . . . . . ....... 711 Journal of Bio-X Research, a Science Partner Journal . . . ..910 Kandu . . . . . . . . . . .......912 LocumTenens.com . . . . . . .... 511 Medtronic . . . . ...523, B3, B5, B15 MenticeInc..............916 MicroTransponder Inc. . . . . ...1031 Moody Neurorehabilitation Institute . . . . . . . . . . ..... 1001 Net Smart & ANVC . . . . . . .... 616 NeuraSignal . . . . . . . . ..... 424 NeuroLogica . . . . . . . . . . . . . 425 NeurOptics..............922 NSALabs. . . . . . . . . ...... 330 Patronus Neurology, LLC . . . ... 317 Penumbra, Inc. . . . . . . . .... 1131 PerimedInc..............507 Precision Neuroscience . . . . . . 611 Pulsara . . . . . . . . . . ...... 506 Q’Apel Medical, Inc. . . . . . ... 806 RapidAI . . . . . . . . . ..... 701, B8 RosmanSearch . . . . . . . ..... 510 Route 92 Medical . . . . ... 1018, B14 SafeSeizure . . . . . . . . ...... 823 SERB Pharmaceuticals . . .. 1118, B9 Sevaro.................416 Siemens Healthineers . . . . .... 719 Solvemed Inc. . . . . . . . . ..... 516 StrokeDx, Inc. . . . . . . . . ....1124 Stryker . . . . . . . . . . ...... 339 SurgeonsLab . . . . . . . . .... 1016 Sutter Health . . . . . . . . ..... 1116 Teladoc Health . . . . . . . .... 805 TeleSpecialists, LLC . . . . . .... 410 Terumo Neuro . . . . . . .... 522, B10 The Joint Commission . . . . ... 948 Twiage. . . . . . . . . . ...... 332 United Biologics, Inc . . . . . ... 945 Vituity.................610 Viz.ai . . . . . . . . . . ....... 430 WallabyPhenox . . . . . . . ....1123 WoltersKluwer. . . . . . . . . . . . 607 World Stroke Organization . . .. 1005 Zeto...................512 The Science & Technology Hall The Science & Technology Hall offers nearly 100 exhibiting companies, HeadQuarters, Learning Studios, Innovation Zone, the Simulation Zone and many more learning and networking opportunities. ISC25 EXHIBITORS Instructions for claiming CE credits 1. Log in to your account a. Go to AHA’s Professional Education Hub. b. Enter your user name and password and sign in. c. Click My Library d. Select the International Stroke Conference 2025 activity. 2. Claim Credit a. Complete the conference evaluation survey. b. Click Claim CE. c. Complete information and Save. d. Your certificate is located in “My Account” under “CE Details.” Note: CE credit for the International Stroke Conference 2025 cannot be claimed after Aug. 7, 2025, and participants are strongly encouraged to claim CE credit within 30 days of the live event. Need assistance? For customer support, call 1-877-340-9899 (8 a.m.- 6 p.m. CST, Monday through Friday) or education.help@ email.education.heart.org. Virtual attendees Request an AHA Certificate of Attendance by choosing the Programming Tab at the top navigation bar on the event platform, then choosing “Certificate of Attendance.” Note: For the ISC 2025 live event, CE credit claim is limited to participation on Feb. 5-7, 2025, only. Scan the QR code for scheduled programming. Welcome First-Time Exhibitors to ISC! These companies are highlighted in red. NEW TO ISC: Neuro Talk Theater in AHA HeadQuarters, Booth 528. Learn, network and relax in the new Neuro Talk Theater. Located in the AHA HeadQuarters, Booth 528, in the Science and Technology Hall, this special learning experience will be open to all attendees on Wednesday and Thursday of the conference.
9 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 : Stop by a Coffee Break for a free coffee or tea Science & Technology Hall hours and location Learning Studio Learn about the latest advances in stroke practices, services and technologies. See today’s schedule of events on page 2. Level 1, Halls H and K | 9 a.m.-4 p.m. | Wednesday and Thursday Simulation Zone Booth 1047 Features hands-on learning in the categories of ischemic stroke, hemorrhagic stroke, stenting/coiling and acute stroke treatment. AHA Head Quarters Booth 528 Learn more about AHA/ ASA initiatives, education, membership and publications.
10 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 Poster Tours, Sessions kick off today ISC 2025 offers three types of poster sessions: new digital posters, professor-led poster tours and one-on-one individual Q&A poster presentations. ISC 2025 Moderated Poster Sessions and Digital Poster Sessions will use Silent Theater. Attendees will want to need to bring personal earphones to audio once they scan a QR code in the poster area. Moderated Digital Poster Sessions (Digital Poster Theaters 1 and 2) Posters DP1 – DP30 12:40-1:10 p.m. • Acute Treatment: Systemic Thrombolysis and Cerebroprotection Moderated Digital Posters (Digital Poster Theater 1) • Cerebrovascular Nursing Moderated Digital Posters (Digital Poster Theater 2) 1:20-1:50 p.m. • Brain Health Moderated Digital Posters (Digital Poster Theater 1) • Cerebrovascular Systems of Care Moderated Digital Posters (Digital Poster Theater 2) 3-3:30 p.m. • Risk Factors and Prevention Moderated Digital Posters I (Digital Poster Theater 1) • Translational Basic Science Moderated Digital Posters I (Digital Poster Theater 2) Professor-Led Poster Tours 6-7 p.m. Posters WMP1 – WMP120 1. Acute Treatment: Systemic Thrombolysis and Cerebroprotection Moderated Poster Tour 2. Brain Health Moderated Poster Tour 3. Cerebrovascular Systems of Care Moderated Poster Tour I 4. Clinical Rehabilitation and Recovery Moderated Poster Tour 5. Health Services, Quality Improvement and PatientCentered Outcomes Moderated Poster Tour I 6. Imaging Moderated Poster Tour I 7. In-Hospital Care: From the ICU to Discharge and Advanced Practice Providers and Therapists Moderated Poster Tour 8. Neuroendovascular Moderated Poster Tour I 9. Risk Factors and Prevention Moderated Poster Tour I 10. Translational Basic Science Moderated Poster Tour I Regular Poster Sessions 7-7:30 p.m. Posters WP1– WP402 These posters are not included in the Wednesday 6 p.m. ProfessorLed Poster Tour Sessions. • Acute Treatment: Systemic Thrombolysis and Cerebroprotection Posters I • Aneurysms and Vascular Malformations Posters • Brain Health Posters I • Cerebrovascular Nursing Posters I • Cerebrovascular Systems of Care Posters I • Clinical Rehabilitation and Recovery Posters I • Health Services, Quality Improvement and PatientCentered Outcomes Posters I • Imaging Posters I • In-Hospital Care: From the ICU to Discharge Posters • Intracerebral Hemorrhage Posters I • Neuroendovascular Posters I • Risk Factors and Prevention Posters • Translational Basic Science Posters I • Late-Breaking Science Posters (LBP1 – LBP69) Digital Poster Sessions 12:40-1:10 p.m. | 1:20-1:50 p.m. | 3-3:30 p.m. Poster Hall, Hall G The sessions will take place in Digital Poster Theater 1 and Digital Poster Theater 2. Expert moderators will lead these sessions, which are organized by category. Each digital poster author will give a short presentation and host a Q&A with digital slides instead of a physical poster. To take part, view the Wednesday Moderated Digital Poster Sessions in the Online Program Planner or on the Mobile Meeting Guide App. Decide which sessions you would like to attend. Then arrive at the corresponding Digital Poster Theater, where you can scan a QR code and listen on your personal device with your earphones. 10 Professor-Led Poster Tours 6-7 p.m. | Poster Hall, Hall G Expert moderators will lead 10 tours. The moderators provide a short presentation and Q&A with each poster author in that category. To take part, view the Wednesday Moderated Poster Sessions in the Online Program Planner or on the Mobile Meeting Guide App. Decide which category of posters you would like to attend. Then, by 5:55 p.m., arrive at the “section” sign numbered for your selected category. The Silent Theater feature will allow you to scan a QR code and listen on your device with your own earphones. Regular Poster Sessions 7-7:30 p.m. | Poster Hall, Hall G Presenters will be at their posters for informal Q&As with attendees. These one-on-one posters are not a part of the Professor-Led Poster Tours. To see the posters featured in today’s Regular Poster Sessions, view the Wednesday Poster Sessions in the Online Program Planner or on the Mobile Meeting Guide App. Posters also will be on display available in the Poster Hall, Hall G, from 8 a.m. to 7:30 p.m. today and Thursday. See Thursday’s Stroke News for details on Thursday’s Moderated Digital Poster Sessions, Professor-Led Poster Tours and Regular Poster Sessions.
11 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 • Acute Treatment: Systemic Thrombolysis and Cerebroprotection • Advanced Practice Providers and Therapists • Aneurysms and Vascular Malformations • Brain Health • Cerebrovascular Nursing • Cerebrovascular Systems of Care • Clinical Rehabilitation and Recovery • Health Services, Quality Improvement and Patient-Centered Outcomes • Imaging • In-Hospital Care: From the ICU to Discharge • Intracerebral Hemorrhage • Large Vessel Disease From Arteries to Veins (Non-Acute Treatment) • Neuroendovascular • Pediatric Cerebrovascular Disease • Risk Factors and Prevention • Translational Basic Science • Late-Breaking Science Abstract categories: Wednesday 6:00 PM Introduction Joshua Goldstein, MD, PhD (Chair) 6:10 PM Code ICH and Early Bundled Care Joshua Goldstein, MD, PhD 6:20 PM Best Practices for Early and Effective Blood Pressure Control in Patients with Intracerebral Hemorrhage Christos Lazaridis, MD, EDIC, BPhil 6:40 PM DOAC Reversal in Patients Experiencing Intracerebral Hemorrhage Ashkan Shoamanesh, MD 7:00 PM Case Presentation and Discussion Case Presenter: Joshua Goldstein, MD, PhD Panelists: Anne Alexandrov, PhD, AGACNP-BC, ANVP-BC, CCRN, FAAN; Christos Lazaridis, MD, EDIC, BPhil; Adnan Qureshi, MD; Ashkan Shoamanesh, MD 7:12PM Case Presentation and Discussion Case Presenter: Adnan Qureshi, MD Panelists: Anne Alexandrov, PhD, AGACNP-BC, ANVP-BC, CCRN, FAAN; Christos Lazaridis, MD, EDIC, BPhil; Joshua Goldstein, MD, PhD; Ashkan Shoamanesh, MD 7:24 PM Question and Answer AGENDA CHAIR Joshua Goldstein, MD, PhD FACULTY Anne Alexandrov, PhD, AGACNP-BC, ANVP-BC, CCRN, FAAN Christos Lazaridis MD, EDIC, BPhil Adnan Qureshi, MD Ashkan Shoamanesh, MD This event is not part of the official International Stroke Conference 2025 as planned by the AHA Committee on International Stroke Conference Programming. This activity is supported by educational grants from AstraZeneca Pharmaceuticals and Chiesi USA, Inc. CHAIR FACULTY This program is sponsored by Wednesday, February 5, 2025 Dinner and Registration: 5:30 PM - 6:00 PM PT Symposium: 6:00 PM - 7:30 PM PT BEST PRACTICES FOR MANAGING INTRACEREBRAL HEMORRHAGE AC Hotel Downtown Los Angeles Main Event Space, 7th Floor 1260 S FIGUEROA ST. • LOS ANGELES, CALIFORNIA PAID ADVERTISEMENT Register online at: WWW.SYMPOSIAREG.COM/22501 Bench to Bedside and Beyond | Adjunctive Neurostimulation Interventions and Therapies to Maximize Post-Stroke Rehabilitation and Recovery 9:15-10:45 a.m. Wednesday | Room 502A Bench to Bedside and Beyond | Understanding Sporadic CSVD Through the Lens of CADASIL and Other Monogenic CSVDS 3:30-5:45 p.m. | Wednesday Room 502B Bench to Bedside and Beyond | What Do We Know About the Role of Inflammation in Intracranial Hemorrhage? 7:30-9 a.m. | Thursday Room 152 Bench to Bedside and Beyond | Attacking the Swell: Vascular Permeability and Cerebral Edema Post-Stroke 3:30-5:45 p.m. | Thursday Room 515A 75 Years of NINDS-Supported Research to Advance Stroke Prevention, Treatment and Recovery: From Bench to Bedside and Beyond 3:30-5:45 p.m. | Thursday Room 151 Advances in Acute Ischemic Stroke Treatment: From Bench to Bedside and Back 4:40-4:50 p.m. | Thursday Room 151 Neurorecovery Post Stroke: Translating Neurovascular Plasticity From Bench to Bedside 5:10-5:20 p.m. | Thursday Room 151 Bench to bedside programming
12 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 ISC Pre-Conference Symposium | HEADS-UP: Health Equity and Actionable Disparities in Stroke — Understanding and Problem-Solving 10:18-10:40 a.m. | Tuesday, Feb. 4 | Room 408AB Edgar J. Kenton III Lecture Virginia J. Howard, PhD, FAHA, FSCT Distinguished Professor of Epidemiology University of Alabama at Birmingham “Recruiting and Retaining Diverse and Underrepresented Participants in Studies of Stroke and Brain Health: It Takes a Village, $$$, Planning, and Long-Term Commitment” This award recognizes lifetime contributions to investigation, management, mentorship and community service in the field of raceethnic stroke disparities or related disciplines. Opening Main Event 11:22-11:35 a.m. | Wednesday, Feb. 5 | Main Event Hall William M. Feinberg Award for Excellence in Clinical Stroke Yongjun Wang, MD China National Clinical Research Center for Neurological Diseases Beijing Tiantan Hospital, Capital Medical University “30 Years of Treatment for Acute Ischemic Cerebrovascular Events: The Power of Evidence” This award recognizes significant clinical science contributions to the investigation and management of stroke. #ISC25 awards honor investigators for their stroke-related research. Abstract-based awards also offer junior investigators opportunities for funding to attend ISC. ISC Main Event Sessions will feature lectures by the Feinberg, Sacco, Sherman and Willis award recipients. Six ISC abstract-based awards will be given at the sessions in which their abstracts are being presented. #ISC25 recognizes awardees ISC 2025 AWARDS Thursday Main Event 11:02-11:15 a.m. | Thursday, Feb. 6 | Main Event Hall Ralph L. Sacco Outstanding Stroke Research Mentor Award Lecture Heather J. Fullerton, MD, MAS Professor of Neurology and Pediatrics University of California, San Francisco “Mentoring to Propel Progress in Pediatric Stroke” This award recognizes outstanding achievements in mentoring future generations of researchers in the field of cerebrovascular disease. 11:17-11:30 a.m. Thomas Willis Lecture Miguel A. Perez-Pinzon, PhD, FAHA Professor of Neurology and Vice Chair for Discovery Science (Neurology) University of Miami Miller School of Medicine Miami, Florida “Nature’s Blueprint for Ischemic Tolerance: Pre- and PostConditioning Strategies” This award recognizes significant basic science contributions to the investigation and management of stroke. Closing Main Event 11:02-11:15 a.m. | Friday, Feb. 7 | Main Event Hall David G. Sherman Lecture Jean-Claude Baron, MD, ScD INSERM, University of Paris Paris, France “50 Years of Deciphering the Pathophysiology of Stroke” This award recognizes lifetime contributions to investigation, management, mentorship and community service in stroke. The Edgar J. Kenton III Lecture was presented during the HEADS-UP pre-conference symposium Tuesday.
13 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 7:30 a.m. | Wednesday, Feb. 5 | Risk Factors and Prevention Oral Abstracts I | Room 515A Mordecai Y.T. Globus New Investigator Award in Stroke Shufan Huo, MD, PhD, New Haven, Connecticut “Integrated Genomic and Proteomic Drug Target Discovery for Ischemic Stroke” (15) This award recognizes Mordecai Y.T. Globus’ major contributions to research in cerebrovascular disease and his outstanding contributions to the elucidation of neurotransmitters’ role in ischemia and trauma, interactions among neurotransmitters, mechanisms of hypothermic neuroprotection and the role of oxygen radical mechanisms and nitric oxide in brain injury. 7:30 a.m. | Wednesday, Feb. 5 | Translational Basic Science Oral Abstracts I | Room 515B Stroke Basic Science Award Heyu Ni, MD, PhD, FCAHS, Toronto “A First-in-Class Humanized Antibody Fragment Targeting Platelet Glycoprotein Ibα: A Comprehensive Preclinical Study of CA1001 for the Treatment of Acute Ischemic Stroke” (89) This award encourages investigators to undertake or continue laboratory-based stroke research in basic or translational science. 7:30 a.m. | Wednesday, Feb. 5 | Acute Treatment: Systemic Thrombolysis and Cerebroprotection Oral Abstracts I | Room 408A Robert G. Siekert New Investigator Award in Stroke Mohamed Elfil, MD, Miami, Florida “Endovascular Thrombectomy Plus Intravenous Thrombolysis Versus Endovascular Thrombectomy Alone in Patients with Large Core Infarct” (2) In recognition of Dr. Robert G. Siekert, founding chair of the American Heart Association’s International Conference on Stroke and Cerebral Circulation, this award encourages new investigators to undertake or continue stroke-related research. 2:12 p.m. | Wednesday, Feb. 5 | Cerebrovascular Systems of Care Oral Abstracts I | Room 152 Stroke Care in Emergency Medicine Award Santosh Murthy, MD, MPH, New York City “Minimally Invasive Surgery Is Associated With Improved Outcomes Compared to Open Craniotomy With Clot Evacuation After Spontaneous Intracerebral Hemorrhage in the AHA Get With The Guidelines Registry” (44) This award encourages investigators to undertake or continue research in the emergent phase of acute stroke treatment and submit an abstract to ISC. 9:15 a.m. | Thursday, Feb. 6 | Brain Health Oral Abstracts | Room 515B Vascular Cognitive Impairment Award Cyprien A. Rivier, MD MSc, New Haven, Connecticut “Integrated Genomic and Proteomic Profiling Support Cathepsin-B as a Drug Repurposing Target in Cerebral Small Vessel Disease” (96) This award encourages investigators to undertake or continue research or clinical work in vascular cognitive impairment and submit an abstract to ISC. 8:30 a.m. | Friday, Feb. 7 | Cerebrovascular Nursing and Advanced Practice Providers and Therapists Oral Abstracts | Room 515B Stroke Rehabilitation Award Mei Zhen Huang, PhD, College Park, Maryland “In-Bed Robot-Guided Ankle Sensory-Motor Rehabilitation in Early Subacute Stroke Survivors: A Preliminary Clinical Trial” (126) This award encourages investigators to undertake or continue research and/or clinical work in stroke rehabilitation and submit an abstract to ISC. Abstract-based awards ISC 2025 AWARDS Use X to post your questions/comments or talk about what is happening at ISC 2025. Use hashtag: #ISC25. Follow ISC on ISC 2026 award nominations AHA Members: Submit your nominations for the ISC 2026 Feinberg, Kenton, Sacco Stroke Mentor, Sherman and Willis Awards. Nomination period opens: Wednesday, Feb. 26, 2025 Nomination period closes: Wednesday Aug. 6, 2025 Go to professional.heart.org/en/meetings/ international-stroke-conference/awardsand-lectures for more information.
14 ISC NEWS DAY 1 | WEDNESDAY, FEBRUARY 5, 2025 StrokeConference.org #ISC25 management of stroke in neonates and children, a comprehensive guide for clinical practice that also highlights gaps in the literature and areas of focus for future studies. Also among Wednesday’s speakers discussing pediatric stroke is Peter Sporns, MD, MHBA, FESO, associate professor in diagnostic and interventional neuroradiology at University Hospital Basel in Switzerland. His presentation, “Endovascular Management of LVO in Pediatric Patients,” will detail the recent results of the Save ChildS Pro study. This prospective, multicenter registry study follows children with arterial ischemic stroke caused by large vessel occlusion who underwent endovascular thrombectomy. “These children had significantly better outcomes than children who received best medical therapy only,” Sporns said. “This study shows that it is important to perform this interventional procedure in eligible children and that there are no major safety concerns.” The session will also delve into data from meta-analyses on endovascular interventions and discuss age limits for these procedures in neonates and infants. According to Sporns, there is no reliable meta-analysis on the age question; the best available data come from the Save ChildS Pro registry. Many neurointerventionalists would agree that in children 6 years and older, endovascular management is feasible and safe in the hands of providers who are experienced in treating children, Sporns said. “Below this age, endovascular management of children with stroke may potentially improve outcomes in selected children, but this is not as wellinvestigated, especially for neonates. It’s very controversial due to different underlying etiologies.” Overall, Pearson noted that to improve pediatric stroke outcomes, focusing on child-specific challenges is key. “Most of these challenges boil down to the fact that children are not ‘little adults.’ Common etiologies and types of strokes differ in pediatrics compared to the adult population. Stroke recovery can look different in a developing brain, and stroke mimics are more common than true stroke in children,” she said. “We must recognize these nuances and be thoughtful in how and when we extrapolate adult stroke therapies to the pediatric population to ensure we are doing the best thing for our patients.” Methodologies in Stroke Trials,” will explore how neurologists can rethink the consent process to meet the challenges of acute stroke trials. Traditional informed consent approaches are impractical because of the critical time window in stroke research. Alternatives such as deferred consent, waiver of consent and advance consent models prioritize ethical integrity while addressing logistical realities, Singh said. These innovations can streamline trial operations, improve recruitment and maintain ethical rigor, she said. Recruiting larger, more diverse study populations is another key challenge. Historically, RCTs have excluded groups including women, the elderly and patients from underrepresented regions, which limits the applicability of findings on a global scale. And conducting large-scale, multinational trials is increasingly expensive, with regulatory hurdles, site training and data harmonization adding to the logistical burden. “As we tackle these challenges, it’s clear that traditional models must adapt to stay relevant,” Singh said. Several promising solutions are on the horizon, Singh said. For example, adaptive trial designs allow researchers to make real-time adjustments based on interim results, such as modifying sample sizes or adding treatment arms. This flexibility accelerates timelines and reduces costs, she said. Technology is another game-changer. “The use of telemedicine for remote recruitment and follow-ups has proven invaluable, especially in the wake of the pandemic,” Singh said. “Additionally, AI-driven data analytics can help us predict patient outcomes and stratify treatments more effectively.” There are other innovative solutions, according to Tolulope Sajobi, PhD, a professor of biostatistics at the University of Calgary Cumming School of Medicine in Alberta. These include integrating wearable devices for long-term and rich data collection (global harmonization and standardization of data); linking multiple data sources (such as electronic health records, registries and omics data); and leveraging digital health platforms for enrollment and outcome assessment. Investing in modern data infrastructures that ensure flexible outcome assessment and data management is critical — and costeffective — for generating robust evidence about the efficacy and effectiveness of interventions, said Sajobi, whose presentation Wednesday is titled “Modernizing Data Infrastructure for Large Global Trials.” “Prioritizing patient-centered data collection and infrastructures that simplify outcomes assessment while providing participants with flexibility to complete their outcomes from anywhere in the world will improve the inclusivity of trials,” he said. In addition, engaging patients in the design phase of trials can ensure that protocols are relevant and feasible, Singh and Sajobi said. “By embracing these innovations, we can make stroke trials more efficient, inclusive and impactful, ultimately improving care on a global scale,” Sajobi said. PEDIATRIC continued from page 3 MODERNIZING continued from page 1 The American Stroke Association is grateful for the continued support and generosity of our exhibitors and sponsors. We want to recognize the following companies for their additional sponsorship and advertising opportunities. • AstraZeneca • BMS/Janssen Alliance • Boston Scientific • Chiesi • Encompass Health • Johnson & Johnson MedTech • Medscape • Medtronic • MicroTransponder, Inc. • National Heart, Lung, and Blood Institute (NHLBI) and the National Institute of Neurological Disorders and Stroke (NINDS) • NeuraSignal • Neurologica • RapidAI • Sevaro • TeleSpecialists • Terumo Neuro • Total CME • Vituity • VoxMedia • Wolters Kluwer Educational grant support provided by: • Boston Scientific Corporation • Chiesi USA, Inc. • DePuy Synthes Products, Inc., d/b/a Cerenovus Sajobi “We must recognize these nuances and be thoughtful in how and when we extrapolate adult stroke therapies to the pediatric population to ensure we are doing the best thing for our patients.” –Rachel Pearson, MD
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