11 A Toolkit for Health Care Professionals Unmet Needs in Hypertension First-line agents include:1-8.1.4, Table 18 Thiazide diuretics Chlorthalidone, 12.5-25 mg/dose, 1 daily Hydrochlorothiazide 25-50m mg/dose, 1 daily Indapamide 1.25-2.5 mg/dose, 1 daily Metolazone 2.5-5 mg/dose, 1 daily ACE (angiotensin converting enzyme) inhibitors Benazepril 10-40 mg/dose, 1-2 daily Captopril 12.5-150 mg/dose,2-3 daily Enalapril 5-40 mg/dose, 1-2 daily Fosinopril 10-40 mg/dose, 1 daily Lisinopril 10-40 mg/dose, 1 daily Moexipril 7.5-30 mg/dose, 1-2 daily Perindopril 4-16 mg/dose, 1 daily Quinapril 10-80 mg/dose, 1-2 daily Ramipril 2.5-20 mg/dose, 1-2 daily Trandolapril 1-4 mg/dose, 1 daily ARBs (angiotensin II receptor blockers) Azilsartan 40-80 mg/dose, 1 daily Candesartan 8-32 mg/dose, 1 daily Eprosartan 600-800 mg/dose, 1-2 daily Irbesartan 150-300 mg/dose, 1 daily Losartan 50-100 mg/dose, 1-2 daily Olmesartan 20-40 mg/dose, 1 daily Telmisartan 20-80 mg/dose, 1 daily Valsartan 80-320 mg/dose, 1 daily CCB (calcium channel blocker) dihydropyridines Amlodipine 2.5-10 mg/dose, 1 daily Felodipine 2.5-10 mg/dose, 1 daily Isradipine 5-10 mg/dose, 2 daily Nicardipine SR 60-120 mg/dose, 2 daily Nifedipine LA 30-90 mg/dose, 1 daily Nisoldipine 17-34 mg/dose, 1 daily CCBnondihydropryidines Diltiazem ER 120-360 mg/dose, 1 daily Verapamil IR 120-360 mg/dose, 3 daily Verapamil SR 120-360 mg/dose, 1-2 daily Verapamil-delayed onset ET, 100-300 mg/ dose, 1 in the evening Secondary agents include:1-8.1.4, Table 18 Diuretics—loop Bumetanide 0.5-2 mg/dose, 2 daily Furosemide 20-80 mg/dose, 2 daily Torsemide 5-10 mg/dose, 1 daily Diuretics— potassium-sparing Amiloride 5-10 mg/dose, 1-2 daily Triamterene 50-100, 1-2 daily Diuretics— aldosterone antagonists Eplerenone 50-100 mg/dose, 1-2 daily Spironolactone 25-100 mg/dose, 1 daily Beta blockers— cardioselective Atenolol 25-100 mg/dose, 2 daily Betaxolol 5-20 mg/dose, 1 daily Bisoprolol 2.5-10 mg/dose, 1 daily Metoprolol tartrate 100-200 mg/dose, 2 daily Metropole succinate 50-200 mg/dose, 1 daily Beta blockers— cardioselective and vasodilator Nebivolol 5-40 mg/dose, 1 daily Beta blockers— noncardioselective Nadolol 40-120 mg/dose, 1 daily Propranolol IR 80-160 mg/dose, 2 daily Propranolol LA 80-160 mg/dose, 1 daily Beta blockers— intrinsic sympathomimetic activity Acebutolol 200-800 mg/dose, 2 daily Penbutolol 10-40 mg/dose, 1 daily Pindolol 10-60 mg/dose, 2 daily Beta blockers— combined alpha and beta receptor Carvedilol 12.5-50 mg/dose, 2 daily Carvedilol phosphate, 20-80 mg/dose, 1 daily Labetalol 200-800 mg/dose, 2 daily Direct renin inhibitors Aliskiren 150-300 mg/dose, 1 daily Alpha-1 blockers Doxazosin 1-16 mg/dose, 1 daily Prazosin 2-20 mg/dose, 2-3 daily Terazosin 1-20 mg/dose, 1-2 daily Central alpha2agonist and other centrally active drugs Clonidine oral 0.1-0.8 mg/dose, 2 daily Clonidine patch 0.1-0.3 mg/dose, 1 weekly Methyldopa 250-1000 mg/dose, 2 daily Guanfacine 0.5-2 mg/dose, 1 daily Direct vasodilators Hydralazine 100-200 mg/dose, 2-3 daily Minoxidil 5-100 mg/dose, 1-3 daily Pharmacotherapy plus lifestyle modification remains the primary treatment for high BP.
RkJQdWJsaXNoZXIy MjI2NjI=