15 #AHA24 ScientificSessions.org Newburger has been continuously funded by the National Institutes of Health since 1982. Her weighted Relative Citation Ratio is 2250, and she has 33 published manuscripts above the 99th NIH percentile for citation. She also maintains a busy clinical practice comprising patients with congenital and acquired heart disease, keeping her grounded regarding important issues affecting the wellbeing of children with heart disease. Stephen G. Young, MD, FAHA University of California, Los Angeles Stephen G. Young is an American physician-scientist known for investigating the genetics and molecular physiology of apolipoprotein B, the intravascular processing of triglyceride-rich lipoproteins by lipoprotein lipase, and the role of nuclear lamins in health and disease. Young is a distinguished professor of medicine and human genetics at UCLA, where he has worked closely with two faculty colleagues (Loren G. Fong, PhD, and Anne P. Beigneux, PhD). Young defined the first APOB mutations causing familial hypobetalipoproteinemia. He discovered that GPIHBP1, a protein of capillary endothelial cells, is crucial for the lipolytic processing of triglyceriderich lipoproteins. GPIHBP1 captures LPL from within the interstitial spaces (where it is secreted by myocytes) and shuttles it across endothelial cells to its site of action within the capillary lumen. In the absence of GPIHBP1, LPL is stranded within the interstitial spaces, resulting in markedly impaired intravascular triglyceride hydrolysis and severe hypertriglyceridemia. He also demonstrated that hypertriglyceridemia in the setting of APOA5 deficiency is caused by reduced amounts of LPL inside capillaries. APOA5 suppresses the ability of the ANGPTL3/ANGPTL8 complex to detach LPL from its binding sites within capillaries. Young studied the history of science at Princeton University and earned a medical degree from Washington University in St. Louis. He trained in internal medicine at the University of California, San Francisco, and cardiovascular diseases at the University of California, San Diego. He is boardcertified in both disciplines. He is a member of the National Academy of Sciences, the American Society for Clinical Investigation and the Association of American Physicians. He is a corresponding member abroad of the Austrian Academy of Sciences and was named an inaugural fellow of the American Society for Biochemistry and Molecular Biology. He has received a Jung Prize in Medicine and an honorary doctorate in medicine from the University of Gothenburg in Sweden. Visit professional.heart.org/en/ meetings/scientific-sessions/ awards for council award recognition. Pick up your copy near the Science & Technology Hall entrance, or scan the QR codes to view online. Take a through Customized agendas for Scientific Sessions 2024
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