9 In Whom Should Lp(a) Be Measured? Because the majority of Lp(a) plasma concentration (up to 90%) is influenced by genetics through the LPA gene4, relative indications for its measurements are: z Family history of premature CVD (men, age <45 years; women, age <55 years). z A personal history of premature CVD. z Individuals with Familial Hypercholesterolemia. z Individuals with family history of elevated Lp(a). Although the 2018 ACC/AHA guidelines3 and the 2019 NLA statement on Lp(a)6 have not recommended measurement of Lp(a) in all individuals, most27-30 but not all31,32, subsequent statements/guidelines contain recommendations for Lp(a) screening in all individuals at least once in a lifetime. However, despite recent guidelines suggesting measurement of Lp(a) in all adults, the testing rate for Lp(a) remains very low. If a decision is made to measure Lp(a), an Lp(a) ≥50 mg/dL or ≥125nmol/L may be considered a risk-enhancing factor for CVD events. Lp(a): A Toolkit for Health Care Professionals Scan to view a video on Lp(a) measurement.
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