11 z In clinical practice, lifestyle modifications and statin therapy are commonly introduced together. The maximum percentage change will occur by four to 12 weeks after starting a statin or combined therapy.3 z Review the need for lifestyle adjustments in eating habits and level of physical activity to maintain a healthy weight or body mass index, and the elimination of tobacco use. Promote a heart healthy lifestyle and provide relevant advice, educational materials or referrals as needed.3 Access the American Heart Association’s Life’s Essential 8™ heart.org/lifes8 The AHA/ACC 2018 Guideline on the Management of Blood Cholesterol recommends assessing 10-year ASCVD risk and focusing on reducing LDL-C, primarily through the use of statin therapy. It advocates for more aggressive lowering of LDL-C on a percentage basis, (e.g., <50%). The AHA/ACC guidelines include a value statement regarding cost considerations for PCSK9 inhibitors.3 Lp(a): A Toolkit for Health Care Professionals Scan to view a video on Life’s Essential 8 and Lp(a).
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