8 • Arterial thrombosis • Inflammation • Endothelial function • Lipid deposition into artery wall High Lp(a) promotes: Lipoprotein(a) – Lp(a) – is composed of an LDL-like moiety that is covalently bound to apolipoprotein(a) – apo(a). Lp(a) Defining and Why It Matters LDL Lp(a) apo(a) 80-90% Genetically determined 6, 7, 8 While not completely defined, Lp(a) is believed to be produced in the liver with proinflammatory and proatherogenic properties. Epigenetic studies show an association between elevated Lp(a) levels and atherosclerotic cardiovascular disease (ASCVD). 9, 10 Lp(a) is: Leading to: • Atherosclerosis • Thrombosis • Calcific aortic stenosis
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