12 4x Intersection of Lp(a) With PAD A retrospective study showed the prevalence of TransAtlantic Inter-Society Consensus (TASC) II class D and severe calcification of femoropopliteal lesions was higher in patients with high Lp(a) than those with low Lp(a).19 Findings from mechanistic, observational, and genetic studies support the causal role of Lp(a) in CVD, including CHD and PAD.19 MALE is 4 times more common in patients with elevated Lp(a). 21 Lp(a) and Major Adverse Cardiovascular Event (MACE) Elevated Lp(a) levels are independently associated with incident MACE and MALE in patients with PAD treated with revascularization irrespective of LDL-cholesterol (LDL-C) level and statin administration. 12 Higher Lp(a) levels are independently associated with an increased risk of MALE in hospitalized patients.4 Elevated Lp(a) levels are associated with an increased risk of MALE in hospitalized patients.20
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