6 How High Is Too High? Lp(a) increases ASCVD risk, especially at higher levels. What Causes High Lp(a) Levels? The major cause of high Lp(a) levels is genetics, mostly reflecting differences in the size of the gene encoding apo(a).5 Meta-analyses have shown increased risk of CVD in individuals with Lp(a) levels ≥125 nmol/L (≥50 mg/ dL).7 According to ACC/AHA dislipidemia guideline, Lp(a) levels ≥125 nmol/L (≥50 mg/dL) constitute a risk enhancing factor.4 z Black people have the highest median Lp(a) levels, followed by South Asian, Hispanic and East Asian peoples. Although, the impact on relative risk of ASCVD is similar regardless of ethnicity/ ancestry.13,14 z Native American people have the lowest Lp(a) levels.15 20% 30% to of the global population1 Elevated levels prevalent in How Common Is It?
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