11 z Good adherence to various LDL-C-lowering diets will reduce LDL-C levels by 10% to >15%. Moderate-intensity statins can be expected to reduce LDL-C levels by an additional 30% to 49%, and highintensity statins by ≥50%. Adding ezetimibe or bempedoic acid to statin therapy typically provides an additional 13% to 30% reduction in LDL-C. Much greater additive reductions occur by adding a PCSK9 inhibitor to statin plus ezetimibe, providing a 43% to 64% reduction.4 z In clinical practice, lifestyle modifications and statin therapy are commonly introduced together. The maximum percentage change will occur by four to 12 weeks after starting a statin or combined therapy.4 z Review the need for lifestyle adjustments in eating habits and level of physical activity to maintain a healthy weight or body mass index, and the elimination of tobacco use. Promote a heart healthy lifestyle and provide relevant advice, educational materials or referrals as needed.4 Lp(a): A Toolkit for Healthcare Professionals The 2026 ACC/AHA Multisociety Dyslipidemia Guidelines recommends assessing PREVENT-ASCVD 10-year risk and treating to LDL-C goals of < 100 mg/dL (< 10% risk) and < 70 mg/dL (≥ 10% risk). Statins recommended as first-line lipidlowering therapy.4 z Access the American Heart Association’s Life’s Essential 8™ heart.org/lifes8
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